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Fiber-rich diets add to these advantages by supplying fermentable substrates that boost SCFA generation, increase regulatory T-cell differentiation, modify microglial maturation, and improve BBB function

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This can interfere with work and everyday life

Findings that would support a primary metabolic defect in copper metabolism include a previously recognized breed predisposition, copper accumulation that precedes cholestasis or inflammation, centrilobular (zone 3) distribution of copper, histochemical score for copper of 3+ or greater, or quantitative copper measurements that exceed 2000 g/g dry weight.54, 57, 66 Special stains of the liver should be requested to evaluate for infectious agents such as leptospirosis