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The purpose of the modeling was to answer questions posed by experiments or experimentalists and to investigate mechanisms of regulation in one-carbon metabolism

Activated NOXs produce superoxide radicals that are converted by the SOD-catalyzed dismutation reaction to hydrogen peroxide

CircRUNX1 also accelerates lung adenocarcinoma cell proliferation and metastasis by targeting the miR-5195-3p/HMGB3 pathway [194]

Taken together, preclinical and clinical studies in neuroblastoma suggest the potential for BSO to enhance L-PAM activity against diseases that use myeloablative dosing of L-PAM and previous investigations with one murine plasmacytoma, 17 and a human MM cell line, 8, 10 demonstrated enhanced activity of L-PAM by BSO