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The use of sdAbs such as [ 68 Ga]Ga-NOTA-Nb1053 allows same-day imaging one hour after injection with high target-to-background ratios, avoiding concerns associated with non-specific bone accumulation seen with 89 Zr-labeled mAb immunoPET techniques

This article covers the specific mechanisms that make the stack viable, the dose protocols researchers are exploring, and the monitoring parameters that distinguish safe co-administration from reckless polypharmacy