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Looking at the X-ray crystal structure of auranofin-trypanothione reductase-NADPH complex, gold was found bound to two cysteine residues (Cys52 and Cys57) while the sugar moiety bound to the docking site from another parasite, L

QZ contributed to the conception of the study and revised the manuscript provided guidance to the manuscript

Some sensor proteins bind DAMPs or PAMPs directly, such as AIM2, which recognizes viral or bacterial double-stranded DNA [303, 304]

A freshly premixed click chemistry reaction cocktail (50 M TAMRA-N 3 from 25 mM stock solution in DMSO, 100 M TBTA from 50 mM stock solution in DMSO, 1 mM TCEP from 1 M stock solution in deionized water, and 1 mM CuSO 4 from 1 M stock solution in deionized water