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While peptides are generally less immunogenic than larger proteins, they can still trigger antibody formation in some patients

Next, we examined the effect of BPC157 on tube formation by HUVECs

GPX4 is required for repression of both canonical CASP1- and non-canonical CASP11-mediated cleavage of GSDMD 56 , indicating that GSH-dependent antioxidant systems do not only inhibit inflammasome assembly but also limit the oxidized membrane environment that favors gasdermin pore formation

An important challenge for future studies will be to define which nodes within this multilayered GSH-centered defense network represent true therapeutic vulnerabilities across different tissue and tumor contexts