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502 Approximately 10% of ALS cases are familial ALS, with various disease-causing genes identified, including superoxide dismutase 1 (SOD1), chromosome 9 open reading frame 72 (C9ORF72), and fused in sarcoma (FUS)

One is to block the import of glutamine by tumor cells specifically

Firstly, although various candidate agents have shown excellent performance in cellular and animal models, clear clinical benefit data are still lacking, and, in particular, no ferroptosis inducers have yet been approved to advance into phase II/III clinical trials