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For the 291 patients who were TMA-negative at the end of therapy, the duration of TMA-negativity on treatment largely determined the likelihood of SVR: 86% of the 125 patients who were noted to be TMA-negative for at least 36 weeks (TMA first negative at week 12), 46% of the 146 patients who were TMA-negative for 24-36 weeks (TMA first negative at week 20 or 24), and none of the 20 patients who had been negative for less than 24 weeks (TMA first negative at week 48) achieved SVR

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J Cancer Tumor Int (2016) 3:17

It is best to take it once in the morning and approx 15-30 minutes before exercise