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Establishment of senescent chondrocytes The mouse embryonic carcinoma-derived chondrogenic cell line ATDC5 was used for in vitro studies

used the Foxp3YFP-Cre Gpx4FL/FL mouse model and found that GPX4-specific deletion in Tregs leads to lipid peroxide accumulation and triggers ferroptosis, accompanied by an increase in the proportion of Th17 cells and an enhanced anti-tumor immune response (151)

The Anshen Dingzhi prescription, from the Qing Dynastys Yi Xue Xin Wu (1732 CE), improves anxiety by activating the SIRT1-PGC-1 pathway, mitigating mitochondrial dysfunction [224]

While these studies have provided an initial look into the COPD transcriptome, their results primarily relied on the use of lung function tests to define the presence or degree of COPD