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Scroggs RS, Fox AP

DAO is responsible for degrading histamine in the digestive tract, while HNMT breaks it down in the central nervous system

DOI: 10.1172/JCI153357 Keinan, O., Valentine, J.M., Xiao, H., Mahata, S.K., Reilly, S.M., Abu-Odeh, M., Deluca, J.H., Dadpey, B., Cho, L., Pan, A., Yu, R.T., Dai, Y., Liddle, C., Downes, M., Evans, R.M., Lusis, A.J., Laakso, M., Chouchani, E.T., Ryde'n, M., Saltiel, A.R

Thus, the gut microbiota can be a major modulator of Kyn pathway in different mental disorders, impairing tryptophan metabolism and influencing the brain and systemic inflammation [226]