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Excessive production of reactive oxygen species (ROS) activates redox-sensitive signalling pathways such as NF-B, leading to sustained release of pro-inflammatory cytokines including TNF-, IL-6, and IL-1, which impair fibroblast function, collagen synthesis, keratinocyte migration, and neovascularisation

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J Pediatr 150(1):7-11 Lowman HB, Chen YM, Skelton NJ, Mortensen DL, Tomlinson EE, Sadick MD, Robinson IC, Clark RG (1998) Molecular mimics of insulin-like growth factor 1(IGF-1) for inhibiting IGF-1:IGF-binding protein interactions

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