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the more negative the Eh value, the more potent the reductant

bcm.edu/news/geriatrics/glutathione-deficiency-fat-insulin-aging Perricone C, et al

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When used with pemetrexed, B12/folic acid therapy further increases sub-G1 populations in human adenocarcinoma and large-cell carcinoma cell lines, independent of p53 status (28)