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Other medications used to treat high blood pressure, such as ACE inhibitors and calcium channel blockers, have also been implicated in causing tinnitus

Mitochondria are regarded as the power station of cells, and they play a key role in maintaining energy metabolism and determining cell vitality (Dong et al., 2019)

This change occurred in parallel with significant up-regulation of antioxidant, inflammatory cytokines, and apoptosis genes

Future research should focus on developing multidimensional predictive models, defining disease-specific dosing regimens, and elucidating synergistic mechanisms with biologics, ultimately achieving the transition from one-size-fits-all to precision interventionthereby opening new avenues for the comprehensive management of immune-mediated diseases