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these genes are conserved in all Ajellomycetaceae included in this analysis (Table S6)

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Rg1 can target and regulate Neurite outgrowth inhibitor-B (Nogo-B)/Ras homolog gene family member A (RhoA) signaling pathway, adjust the polarization ratio of M1 and M2 macrophages, promote upregulation of NLRP12 expression, and suppresses IL-1 and TNF- through TLR4 signaling pathway, further restoring the balance of anti-inflammatory and pro-inflammatory factors (Zhu et al., 2017

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J Clin Invest 94: 17921798

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PMID: 39984485

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