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Although PYC has been shown to reduce CRP levels, existing trials are limited by small sample sizes (e.g., five studies totaling approximately 324 participants in a CRP meta-analysis), high heterogeneity (I 2 99%), and variability in dosing regimens, treatment duration, and study populations ( Similarly, although PYCs anticancer effects have been demonstrated in multiple cell lines and preclinical models, translational data remain limited

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Muscle spasm, trigger points, local inflammation, skin hypersensitivity, sleep disturbance, metabolic factors, nutritional deficiencies, and central sensitization can all maintain pain after shingles

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