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Nevertheless, in this IR conformation, the L1FnIII-2 interaction in the bottom part of the receptor, which is critical for IGF1R activation, seems to become much weaker and is thus unlikely to be functionally important for IR activation

Sun C, Sun Y, Jiang D, Bao G, Zhu X, Xu D, et al

Stroke Cerebral stroke, which includes ischemic and hemorrhagic types, remains one of the leading causes of death and prolonged disability globally, frequently leading to permanent brain injury [134]

They found that both sugar-based protectants (like trehalose) and protein-based protectants (like CAHS D proteins) could prevent the degradation of FVIII under repeated cycles of drying and rehydration