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However, some patients may react to other components in the injection formulation

Essential branched-chain amino acids (BCAAs) such as isoleucine, leucine and valine, are key both for protein synthesis and increased energy demand [70], so metastases must obtain them from circulation or surrounding tissues

A deep understanding of the chemical classification of these compounds not only aids in elucidating their pharmacological mechanisms but also provides a theoretical basis for predicting their pharmacokinetic behaviors (e.g., membrane permeability, metabolic stability) and potential clinical translation barriers

They are often combined with PRP for accelerated, synergistic results