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Hypoxic tumor microenvironment: implications for cancer therapy

doi: 10.1007/s10815-019-01555-1 259 MaieseK

In addition, TAMs express CCL22, attract Tregs to increase the production of molecules such as PD-L1, disrupt T-cell metabolism by expressing ARG1, and deprive T cells of L-arginine, a key nutrient for T-cell growth 270