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Therefore, ferroptosis can be induced by diverse FINs, classified into distinct classes according to their targets and mechanisms

found in their study that in clear cell renal cell carcinoma (ccRCC) tumor cells, endogenous Gln metabolism might reduce the anti-tumor effectiveness of T cells by promoting the Treg cell response ( 2.1.4 Regulation of tumor cell redox homeostasis Gln regulates the redox status of cancer cells by influencing the production of mitochondrial ROS

5.5 Radiation Recall Radiation recall can occur with pemetrexed in patients who have received radiation weeks to years previously