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It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, and alterations and modifications in the illustrated invention, and further applications of the principles of the invention as illustrated therein are herein contemplated as would normally occur to one skilled in the art to which the invention relates

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Experimental studies suggest that inhibition of NNMT may increase intracellular nicotinamide availability, thereby supporting NAD biosynthesis and improving mitochondrial oxidative metabolism