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doi: 10.3390/ijms26125823 370 LiaoJ-FChengY-FYouS-TKuoW-CHuangC-WChiouJ-Jet al

Researchers who are sensitive to gastrointestinal side effects or who have experienced significant issues with semaglutide constipation or tirzepatide GI issues may find cagrilintide monotherapy more tolerable, even at the cost of somewhat lower weight loss

Protocols discussed in research communities typically involve Retatrutide at 2 to 8 mg weekly alongside Tesamorelin at 2 mg daily, with sequential introduction recommended to assess individual tolerance