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Additionally, in phase 2 studies in people with MASH and liver fibrosis, survodutide not only significantly improved liver steatosis, but also led to histologic improvement of MASH without worsening fibrosis in 4362% of participants, versus 14% with placebo [41]

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Nevertheless, the potency for CGRP receptor activation was enhanced by 4.7-fold with CGRP N31D/S34P/K35W/A36S mutations [28,29]