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Similarly, at the mRNA level, an inverse correlation between TIMP gene expression and IOP (r = 0.93)

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In a subsequent study, the authors reported an increase in LPO and nitric oxide (NO) levels, together with significant alterations in GSH redox status in the blood of male Wistar albino rats (age 2 months) exposed to drinking-water containing aspartame at a dose of 40 mg/kg bw for 6 weeks (Proki et al., 2015)

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