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Most recently, several studies have implicated acetylcholine (ACh) receptors (both nicotinic and muscarinic) [82, 83, 85] and transient receptor potential (TRP) channel [63, 64, 157] dysfunction in the peripheral blood mononuclear cells (PBMCs) of ME/CFS donors

Although it seems this bidirectional connection is guided by various mechanisms, there is no definitive epidemiological evidence linking gut dysbiosis, the CNS, and the peripheral immune system (see Fig

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