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There is a notable association between the expression of connexin 32 (Cx32), which is a critical component of GJs, and the onset of APAP-induced hepatotoxicity (Patel et al

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The nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012