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J Pediatr;MassaerF.MeucciV.SaggeseG.SoldaniG.2008 190

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Long-term exposure to metals, including copper, iron, and manganese, increases the risk of PD, possibly due to the elevation in ROS levels mediated by the Fenton reaction or the aggregation of SNCA [178, 179]

Therefore, experiments based on specific antagonists, agonists against the receptors, and blocking antibodies should be employed for the interpretation of the observations