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Description

J Am Acad Child Adolesc Psychiatry 57:867875

Amaral JD, Viana RJ, Ramalho RM, Steer CJ, Rodrigues CM

By employing network pharmacology modeling and broad counter-screening early on, developers can manage polypharmacologyleveraging it to enhance efficacy (through synergistic target engagement) and using informatics to avoid trap compounds that bind irrelevant or harmful targets