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Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants

AHK-Cu is not an FDA-approved drug

the predicted binding mode of 1j indicates the C5-amino substituent forms hydrogen bonding interaction with the carboxylic backbone of the Ser201 residue and a hydrophobic bonding with the Ser213 residue unlike the NCA amide group that is in hydrogen bonding distance from with the NNMT Ser213 residue