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This approach is standard in medicinal chemistry since it allows the generation of marketable analogues of a known drug that has an intellectual property composition of matter [41]

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Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart

DOSAGE AND ADMINISTRATION The storage, preparation, and administration information in this Fact Sheet apply to the Pfizer-BioNTech COVID-19 Vaccine for individuals 12 years of age and older, which is supplied in a multiple dose vial with a purple cap and MUST BE DILUTED before use