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In addition, the absence of the P53 tumor suppressor gene can obstruct Gln utilization by decreasing GLS2 levels inside cells and boosting ROS levels (68)

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1), were hardly detectable during the culture, both in the cell and supernatant (data not shown)

Restoration of mitochondrial function in SN and modulation of plasma inflammatory cytokine responses Mitochondrial function in SN neurons was examined by analyzing expression of proteins of the electron transport chain and oxidative damage using 8-hydroxy-2-deoxyguanosin (8-OHdG) staining