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Nfkb1 knockin mice that express p50 but not its precursor, the IB-like molecule p105, display aberrant NF-B activation and spontaneously develop colitis characterized by hyperproduction of Th17 cells

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The copper uglies usually show up as redness, sensitivity, small bumps, sometimes acne-like breakouts, and a temporary worsening of skin tone or texture

106 These findings are consistent with the role of NF-B in mediating induction of pro-inflammatory cytokines in innate immune cells and the differentiation Th1 and Th17 subsets of inflammatory T cells