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50% of the bodys storage of vitamin B12 is kept within the liver, no matter how it is administered, so if the liver is sick, in all likelihood, a person can suffer B12 deficiency

5-amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine (SAM)