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While associated with progression in colorectal, liver, pancreatic, and breast cancers through mechanisms like endothelial NF-B/vascular endothelial growth factor A (VEGFA)-driven angiogenesis and periostin (POSTN)-mediated Integrin-linked protein kinase (ILK)/AKT/mTOR activation that fuels EMT and metastasis in hepatocellular carcinoma (HCC) (172176), TMAO simultaneously enhances ICI response via context-dependent immunostimulationwith causality established through multiple experimental approaches

Meehan CA, Cochran E, Kassai A, Brown RJ, Gorden P

2F, G and Supplementary Fig

Ralli M, Angeletti D, Fiore M, DAguanno V, Lambiase A, Artico M, de Vincentiis M, Greco A