glutamate glutathione redox cycle. Glutathione (GSH) is synthesized from the This schematic illustrates the central

10.3390/jcm9124036 3 Baroja-MazoA.Martin-SanchezF.GomezA

Concurrent Use with Other NNMT Inhibitors or Methylation Modulators Combining with supplements or drugs that also inhibit NNMT or alter methylation (e.g., SAMe , niacin , methylfolate , resveratrol ) could lead to: Excess NAD accumulation Methyl donor depletion Unpredictable metabolic effects Use caution and monitor methylation-related pathways if stacking 3

Deep Brain Stimulation (DBS) & Surgical Interventions for PD For some patients with Parkinsons who do not respond well to medication, they may be offered brain surgery as a treatment option

Evidence for involvement of furin in cleavage and activation of diphtheria toxin