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In addition, NAPQI also deactivates some of the enzymes that recycle GSH, such as GSH peroxidase

PMID: 27633659

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If attacks are severe enough to require hospitalization or cause substantial absenteeism from school or work [21] Prophylactic medications include: Amitriptyline First line 75-100mg per day More effective in those with family history of migraines Anticonvulsants (topiramate, zonisamide, levetiracetam) Second line Topiramate (100mg), zonisamide (400mg), levetiracetam (1000mg) Mitochondrial supplementation Adjunctive therapy Very limited evidence Coenzyme Q10 (200mg BID), Riboflavin (200mg BID) [15]