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The protocol is typically administered as subcutaneous injections over a 4-week or 8-week cycle

Affinity tags were cleaved by TEV protease at 4 C for 1 h before proceeding directly to SEC, which was performed on a Superdex 200 Increase 10/300 GL column (GE Healthcare) as described above

Persisting eosinophils in endoscopically inactive tissue forewarn mucosal immunologic activity that can herald relapse

Substrate-level phosphorylation Substrate-level phosphorylation produces ATP from another high energy phosphate compound Phosphoglycerate kinase (PGK) catalyzes transfer of the phosphate group from the high-energy acyl phosphate of 1,3-BPG to ADP, forming ATP