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The triple-active formula works through three complementary pathways: Lidocaine HCl (40mg) for fast-onset primary pain relief, Tetracaine HCl (20mg) for extended numbing duration beyond what lidocaine alone provides, and Epinephrine HCl (0.8mg) as a vasoconstrictor that slows anesthetic absorption into the bloodstream prolonging local effect and reducing procedural bleeding

Additionally, data from a Phase I clinical trial (NCT02861300) indicated that the combination of CB-839 and capecitabine which is a prodrug of 5-FU, was well tolerated by CRC patients at bioactive doses

In acute ANIT model and Mdr2-/- model, the serum ALT of HLX92 was over 2 times less than cholestatic control, which also showed superior efficacy in ameliorating liver injury to UDCA and OCA

In addition, the combination of multiple drugs also provides a new direction for future treatment ideas