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doi: 10.1016/j.biopha.2017.02.016 16

The FDA does not review compounded drugs for safety, effectiveness, or quality

Each run was conducted with one mouse from each treatment group and with run-to-run alternation so that treatments were equally distributed across all four arenas

Additionally, a large survey of over 2000 transmasculine patients on TRT revealed the following: 33.3% developed acne with injected testosterone 48.6% experienced acne with transdermal testosterone So while incidence varies, multiple studies suggest variables like dosage, duration, and genetics impact acne risk