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It is noteworthy that SARS-CoV-2 has a high mutation rate, and numerous mutant strains (variants) have been reported

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3.4 Other regulatory mechanisms of ferroptosis There are several classical signaling pathways, which either synergize with ferroptosis or act as upstream regulatory signals that influence cancer cell survival and proliferation, including PI3K/Akt, Wnt/-catenin, p53, ACSL4, Caspase-1-dependent pyroptosis, and AMP-activated protein kinase (AMPK)/ Beclin1 (BECN1) signal pathways

20 NRF2 was first identified in 1994, 21 and by 1996, 22 it had been discovered that under oxidative stress conditions, it could activate the expression of antioxidative enzyme genes, including NQO1, GPX4, TXN, and PRDX1