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2.1 Molecular mechanisms of Sunitinibs anti-tumor activity in RCC Sunitinib is classified as a multi-targeted TKI that inhibits angiogenesis and tumor growth by targeting tyrosine kinase (RTK) receptors, including vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), cellular homolog of the v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene (c-Kit/kit), and FMS-like tyrosine kinase 3 (FLT3) (Sweeney et al., 2023) (Figure 1)

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Yet, individuals with pre-existing conditions may be at increased risk of serious adverse effects (including death) if one considers the possibility that large doses of supplemental vitamin E might interfere with medications, and possibly lower their efficacy or increase their toxicity (1)