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Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up

Somatostatin analogs including octreotide, lanreotide, and pasireotide treat neuroendocrine tumors by binding to somatostatin receptors on tumor cells

Animal models show a 1224% increase in median and maximum lifespan

It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation