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SSMD was first reported by Sedaghatian (after which the disorder is eponymously named) in 1980, reporting two brothers in Iran who each died within the first week of birth, and finding severe congenital metaphyseal involvement, mild rhizomelic shortness of upper limbs, and mild platyspondyly

Yet another link to the evolutionary requirement for H 2 in eukaryotes are the hydrogenase enzymes found in many species of photosynthesising organisms, including algae and higher plants

Int J Mol Sci 24:728

The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells