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This transformation blocks melanin production by latching onto the tyrosinase enzyme found in melanocytes the cells responsible for producing melanin pigment, which darkens the skin

During ischemia, hypoxia-induced damage leads in the release of DAMPs, such as high-mobility group box-1 protein (HMGB1) and heat shock proteins (HSPs), which activate pattern recognition receptors (PRRs) such toll-like receptors (TLRs) on immune cells (Fernndez et al., 2020

In addition to ROS overproduction, the activation of MAPK and inactivation of phosphatidylinositol 3-kinase/Akt (a serine/threonine kinase that is also known as protein kinase B)/mammalian target of rapamycin (mTOR) are associated with both apoptosis and autophagy 6