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(2025) Ethics declarations Competing interests The authors declare no competing interests

Copper chelating active substance (e.g., D-penicillamine) induce phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) expression, which upregulates NOXA protein, a necessary condition for melanoma cell death, highlighting the potential of targeting copper homeostasis as a therapeutic strategy (Qiao et al., 2012)

For those of you on a vegetarian or vegan diet, focus on these vegan high-protein foods to increase your consumption: tempeh lentils beans (black beans, lima beans, pinto beans, chickpeas) nuts (almonds, peanuts, pistachios, cashews) nut butter (almond butter, cashew butter, sunflower seed butter) brown rice oats quinoa seeds (chia seeds, flaxseeds, pumpkin seeds, hemp seeds) leafy greens (spinach, kale) Plant proteins also provide fiber, antioxidants and phytonutrients, making them valuable additions to a high-protein diet, especially when a variety of sources are consumed

Moreover, smoking may influence the progression of RA by affecting histone modifications