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In order to create an environment supportive of these innovations in irAE research and clinical care, several institutions have set up multidisciplinary immune-related toxicity teams 20

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia

3.1.6.3 NLRP3 inflammasomes The multiprotein complex known as the NLRP3 inflammasome triggers caspase-1, which results in the maturation and release of the pro-inflammatory cytokines IL-1 and IL-18 [166,167,168]