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Groopman JD, Wild CP, Hasler J et al (1993) Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans

PJBS 13 , 7377 (2010)

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Hypermethylation of the transporter 1 ATP-binding cassette subfamily B member (TAP1) has been shown to suppress TAP1 expression in immunoreactive cancer stem cells (CSCs) within murine models of breast carcinoma, these CSCs manifest a downregulation in the expression of transporter associated with antigen processing genes and co-stimulatory molecules, thereby reducing their sensitivity to T-cell-mediated immune surveillance and potentially culminating in immunotherapy resistance