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Acta Pharmacologica Sinica 42(10):15751586 Ma TL, Chen JX, Zhu P, Zhang CB, Zhou Y, Duan JX (2022) Focus on ferroptosis regulation: exploring novel mechanisms and applications of ferroptosis regulator

KEAP1 acts as an OS sensor to regulate NRF2 turnover within the cell/body, while NRF2 activation leads to the production of antioxidant and detoxifying substances that decrease OS [66,67,68]