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10.1074/jbc.M100020200 49 GoncalvesS.PaupeV.DassaE

see below), which may be the reason for the lack of efficacy in some of these trials

The McCoy 2013 paper, which introduced and characterized Dihexa as the metabolically stabilized lead from the Harding laboratorys Ang IV-analog series, used scopolamine-induced cognitive impairment in young rats and natural cognitive decline in aged rats as the primary Morris water maze readouts