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Id probably bring Marty [Makary] on as well from the FDA

Both showed efficacy but neither completed the full approval process

compared healthy (high-fiber) and unhealthy (high-cholinergic) diets and found that the TMAO produced by the diet is only partially related to the degree of atherosclerosis, because a high-cholinergic diet may work through a series of pro-inflammatory and platelet activations, rather than single mediators ( ApoE / mice ( Table 2 The positive or non-effects of trimethylamine-N-oxide (TMAO) on atherosclerosis demonstrated via clinical and non-clinical experiments

Its physiological meaning likely depends on sampling design, timing, sleep-related factors, and context-specific state variability ( Flattened diurnal decline