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Name: swollen feet klow blood pressure Does Impact Your Feet? Lower Extremity Edema – Causes,
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doi: 10.1053/j.gastro.2016.10.012 4

Academic Press, New York

doi: 10.36380/scil.2020.wvj56 11 JangJYKimDImEKimND

Two signaling mechanisms are involved in the GPx1-dependent regulation of the apoptosis pathway: (1) GPx1 regulates the level of cytosolic H 2 O 2 that oxidizes the redox protein thioredoxin 1, blocking ASK1 activation, and (2) GPx1 interacts with TRAF2 and interferes with the formation of the active ASK1 complex