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The drug-induced activation of the D1 dopamine receptor in the mesolimbic pathway (from VTA to NAc) and inhibition of D2 receptors in the striatocortical pathway (from the cerebral cortex to striatum) are classically associated with reinforcing, positive drug effects present during binge stage even though -opioid receptors and endocannabinoid systems are also involved (Volkow and Morales, 2015)